دانلود مقاله : Bone Complications of Mastocytosis: A Link between Clinical and Biological Characteristics 2013
دانلود مقاله :
Bone Complications of Mastocytosis: A Link between Clinical and Biological Characteristics 2013
نویسندگان :
Nicolas Guillaume, ,a1 Judith Desoutter, MD,a1 Olivia Chandesris, MD,c Lavinia Merlusca, MD,d Isabelle Henry, MD,e ophie Georgin-Lavialle, MD,c,f Stéphane Barete, MD,g Isabelle Hirsch, PhD,cDaoud Bouredji, MD,h Bruno Royer, MD,d Bérengère Gruson, D,d Catherine Lok, MD, PhD,i Henri Sevestre, MD, PhD,jRomuald Mentaverri, PhD,k Michel Brazier, MD, PhD,a,k Jonathan Meynier, hD,l Olivier Hermine, MD, PhD,b,cJean-Pierre Marolleau, MD, PhD,d Said Kamel, Pharm D, PhD,k Gandhi Damaj, MDc
فرمت:pdf
چکیده :
OBJECTIVES: Mastocytosis is a heterogeneous group of clonal mast cell disorders in which bone manifestations
are frequently seen, but poorly understood. In this study, we analyzed correlation of clinical
findings in mastocytosis patients with bone mineral density and bone turnover markers.
METHODS: Serum levels of bone turnover markers were measured in mastocytosis patients and healthy
volunteers. Bone disease was evaluated using radiographic imaging, and measurement of bone mineral density.
RESULTS: Of 45 adult mastocytosis patients, bone abnormalities were detected in 34 (75%). Bone lesions
were documented on radiographic imaging in 16 patients (36%), and bone mineral density in 24 patients
(53%), of which 9 patients (20%) had osteoporosis and 15 (33%) had osteopenia. Serum levels of bone
turnover markers that evaluate bone resorption (C-telopeptide, deoxypyridinoline), bone formation (bonespecific
alkaline phosphatase), and bone remodeling (osteoprotegerin) were significantly higher in the
patient population than in the control population (n28). Levels of C-telopeptide and osteoprotegerin
were higher in patients with advanced systemic mastocytosis than in patients with cutaneous or indolent
systemic mastocytosis. Moreover, C-telopeptide and osteoprotegerin levels were significantly correlated
with those of serum tryptase, a diagnostic marker of mastocytosis.
CONCLUSION: The observed bone turnover markers variations indicate a complex process of bone turnover
in mastocytosis-related bone manifestations. The highly significant correlation between serum tryptase and
serum bone turnover markers levels, and the positive correlation of levels of bone turnover markers with
advanced disease, support the existence of a link between bone remodeling and mast cell burden.
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